Elodie Ghedin, PhD

Associate Professor
Center for Vaccine Research,
Department of Computational and Systems Biology
BST3, Room 9043b
3501 5th avenue
Pittsburgh, Pennsylvania 15261
Phone: (412) 383-5850
E-mail: <elg21 AT SPAMFREE pitt DOT edu>
Alternative Webpage

Google Scholar Profile

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Biography:

Elodie Ghedin earned her B.S. and Ph.D. from McGill University in Canada and was a postdoctoral fellow at the National Institute of Allergy and Infectious Diseases (NIAID) (1998-2000).

The underlying theme in Dr. Ghedin’s research is the genomics of infectious diseases. She has worked on the causative agents for African sleeping sickness, Chagas disease, cutaneous and visceral leishmaniases, and lymphatic filariasis. During her time at The Institute for Genomic Research (TIGR, 2000-2006) Dr. Ghedin led the Viral Genomics group, working on the design of high throughput pipelines for virus discovery and characterization. Her laboratory was the first to produce an efficient and rapid workflow for the systematic decoding of complete influenza genomes. In September 2011, Dr. Ghedin was selected as a MacArthur Fellow, recognized for using genomic studies to reveal critical information about human pathogens.

Research Interests:

  • Influenza evolutionary dynamics
  • Parasite Genomics
  • Microbiome studies

Selected Publications:

  • Ghedin, E., Laplante, J., DePasse, J., Wentworth, D.E., Santos, R.P., Lepow, M.L., Porter, J., Stellrecht, K., Lin, X., Operario, D., Griesemer, S., Fitch, A., Halpin, R.A., Stockwell, T.B., Spiro, D.J., Holmes, E.C., St.George, K. (2011) Deep sequencing reveals mixed infection of pandemic H1N1/2009 viruses and the emergence of oseltamivir resistance. J. Infectious Diseases Jan;203(2): 168-174.

  • Ghedin, E., Wentworth, D., Halpin, R.A., Lin, X., Bera, J., DePasse, J., Fitch, A., Griesemer, S., Hine, E., Katzel, D.A., Overton, L., Proudfoot, K., Sitz, J., Szczypinski, B., St. George, K., Spiro, D.J., Holmes, E.C. (2010) Unseasonal Transmission of H3N2 Influenza A Virus during the Swine-Origin H1N1 Pandemic J. Virology Jun;84(11):5715-5718.

  • Ghedin, E., Hailemariam, T., DePasse, J., Zhang, X., Oksov, Y., Unnasch, T.R., Lustigman, S. (2009) Brugia malayi gene expression in response to the targeting of the Wolbachia endosymbiont by tetracycline treatment. PLoS Negl. Trop. Dis. Oct.6;3(10):e525

  • Ghedin, E., Fitch, A., Boyne, A., Griesemer, S., DePasse, J., Bera, J., Zhang, X., Halpin, R.A., Smit, M., Jennings, L., St George, K., Holmes, E.C., Spiro, D.J. (2009) Mixed Infection and the Genesis of Influenza Virus Diversity. J. Virology Sep;83(17): 8832-8841.

  • Ghedin, E., Wang, S., Spiro, D.J., Caler, E., Zhao, Q., Crabtree, J., Allen, J.E., Delcher, A.L., Guiliano, D.B., Miranda-Saavedra, D., Angiuoli, S.V., Creasy, T., Amedeo, P., Haas, B., El-Sayed, N.M., Wortman, J.R., Feldblyum, T., Tallon, L., Schatz, M., Shumway, M., Koo, H., Salzberg, S.L., Schobel, S., Pertea, M., Pop, M., White, O., Barton, G.J., Carlow, C.K.S., Crawford, M.J., Daub, J., Dimmic, M.W., Estes, C.F., Foster, J.M., Ganatra, M., Gregory, W.F., Johnson, N.M., Jin, J., Komuniecki, R., Korf, I., Kumar, S., Laney, S., Li, B.-W., Li, W., Lindblom, T.H., Lustigman, S., Ma, D., Maina, C., Martin, D., McCarter, J.P., McReynolds, L., Mitreva, M., Nutman, T.B., Parkinson, J., Peregrín-Alvarez, J.M., Poole, C., Ren, Q., Saunders, L., Sluder, A.E., Smith, K., Stanke, M., Unnasch, T.R., Ware, J., Wei, A.D., Weil, G., Williams, D.J., Zhang, Y., Williams, S.A., Fraser-Liggett, C., Slatko, B., Blaxter, M.L., Scott, A.L.. (2007) Draft Genome Sequence of the Filarial Nematode Parasite Brugia malayi. Science 317: 1756-1760.

  • Bringaud, F., Müller, M., Coutinho Cerqueira, G., El-Sayed, N.M.A., Papadopoulou, B., and Ghedin, E. (2007) A Large Family of Extinct Short Retroposons is Involved in the Regulation of Gene Expression in Leishmania. PLoS Pathogens. Sep 7;3(9):1291-307

  • Bringaud F, Bartholomeu DC, Blandin G, Delcher A, Baltz T, El-Sayed NM, Ghedin E. (2006) The Trypanosoma cruzi L1Tc and NARTc non-LTR retrotransposons show relative site specificity for insertion. Mol Biol Evol. Feb;23(2):411-20.

  • Ghedin E, Sengamalay NA, Shumway M, Zaborsky J, Feldblyum T, Subbu V, Spiro DJ, Sitz J, Koo H, Bolotov P, Dernovoy D, Tatusova T, Bao Y, St George K, Taylor J, Lipman DJ, Fraser CM, Taubenberger JK, Salzberg SL. (2005) Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolution. Nature. Oct 20;437(7062):1162-6.

  • Holmes EC, Ghedin E, Miller N, Taylor J, Bao Y, St George K, Grenfell BT, Salzberg SL, Fraser CM, Lipman DJ, Taubenberger JK. (2005) Whole-genome analysis of human influenza A virus reveals multiple persistent lineages and reassortment among recent H3N2 viruses. PLoS Biology Sep;3(9):e300.

  • Berriman M, Ghedin E, Hertz-Fowler C, Blandin G, Renauld H, Bartholomeu DC, Lennard NJ, Caler E, Hamlin NE, Haas B, Bohme U, Hannick L, Aslett MA, Shallom J, Marcello L, Hou L, Wickstead B, Alsmark UC, Arrowsmith C, Atkin RJ, Barron AJ, Bringaud F, Brooks K, Carrington M, Cherevach I, Chillingworth TJ, Churcher C, Clark LN, Corton CH, Cronin A, Davies RM, Doggett J, Djikeng A, Feldblyum T, Field MC, Fraser A, Goodhead I, Hance Z, Harper D, Harris BR, Hauser H, Hostetler J, Ivens A, Jagels K, Johnson D, Johnson J, Jones K, Kerhornou AX, Koo H, Larke N, Landfear S, Larkin C, Leech V, Line A, Lord A, Macleod A, Mooney PJ, Moule S, Martin DM, Morgan GW, Mungall K, Norbertczak H, Ormond D, Pai G, Peacock CS, Peterson J, Quail MA, Rabbinowitsch E, Rajandream MA, Reitter C, Salzberg SL, Sanders M, Schobel S, Sharp S, Simmonds M, Simpson AJ, Tallon L, Turner CM, Tait A, Tivey AR, Van Aken S, Walker D, Wanless D, Wang S, White B, White O, Whitehead S, Woodward J, Wortman J, Adams MD, Embley TM, Gull K, Ullu E, Barry JD, Fairlamb AH, Opperdoes F, Barrell BG, Donelson JE, Hall N, Fraser CM, Melville SE, El-Sayed NM. (2005) The genome of the African trypanosome Trypanosoma brucei. Science. Jul 15;309(5733):416-22.

internal: Influenza Genome Project Pages